Proteins Do Not Replicate, They Precipitate: Phase Transition and Loss of Function Toxicity in Amyloid Pathologies

SIMPLE SUMMARY: Amyloid aggregation of proteins in disease has been known for over a hundred years; however, effective therapeutics for amyloid pathologies such as Alzheimer’s disease and Parkinson’s disease are still lacking. This review divides the amyloid phenomenon into four major questions: Wha...

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Detalles Bibliográficos
Autores principales: Ezzat, Kariem, Sturchio, Andrea, Espay, Alberto J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031251/
https://www.ncbi.nlm.nih.gov/pubmed/35453734
http://dx.doi.org/10.3390/biology11040535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031251/
https://www.ncbi.nlm.nih.gov/pubmed/35453734
http://dx.doi.org/10.3390/biology11040535

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