A Fluorescence-Polarization-Based Lipopolysaccharide–Caspase-4 Interaction Assay for the Development of Inhibitors

Recognition of intracellular lipopolysaccharide (LPS) by Caspase-4 (Casp-4) is critical for host defense against Gram-negative pathogens. LPS binds to the N-terminal caspase activation and recruitment domain (CARD) of procaspase-4, leading to auto-proteolytic activation followed by pro-inflammatory...

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Detalles Bibliográficos
Autores principales: An, Jinsu, Kim, So Yeon, Yang, Eun Gyeong, Chung, Hak Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032125/
https://www.ncbi.nlm.nih.gov/pubmed/35458656
http://dx.doi.org/10.3390/molecules27082458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032125/
https://www.ncbi.nlm.nih.gov/pubmed/35458656
http://dx.doi.org/10.3390/molecules27082458

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