Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media

The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of important questions addressing food effects is limit...

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Detalles Bibliográficos
Autores principales: Ye, Dong, López Mármol, Álvaro, Lenz, Verena, Muschong, Patricia, Wilhelm-Alkubaisi, Anita, Weinheimer, Manuel, Koziolek, Mirko, Sauer, Kerstin A., Laplanche, Loic, Mezler, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032137/
https://www.ncbi.nlm.nih.gov/pubmed/35456533
http://dx.doi.org/10.3390/pharmaceutics14040699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032137/
https://www.ncbi.nlm.nih.gov/pubmed/35456533
http://dx.doi.org/10.3390/pharmaceutics14040699

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