Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones

A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared via the previously known protocols, as 2-aminofuran derivati...

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Autores principales: Aksenov, Nicolai A., Aksenov, Dmitrii A., Kurenkov, Igor A., Aksenov, Alexander V., Skomorokhov, Anton A., Prityko, Lidiya A., Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032200/
https://www.ncbi.nlm.nih.gov/pubmed/35479147
http://dx.doi.org/10.1039/d1ra02279b
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author Aksenov, Nicolai A.
Aksenov, Dmitrii A.
Kurenkov, Igor A.
Aksenov, Alexander V.
Skomorokhov, Anton A.
Prityko, Lidiya A.
Rubin, Michael
author_facet Aksenov, Nicolai A.
Aksenov, Dmitrii A.
Kurenkov, Igor A.
Aksenov, Alexander V.
Skomorokhov, Anton A.
Prityko, Lidiya A.
Rubin, Michael
author_sort Aksenov, Nicolai A.
collection PubMed
description A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared via the previously known protocols, as 2-aminofuran derivatives were produced instead.
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spelling pubmed-90322002022-04-26 Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones Aksenov, Nicolai A. Aksenov, Dmitrii A. Kurenkov, Igor A. Aksenov, Alexander V. Skomorokhov, Anton A. Prityko, Lidiya A. Rubin, Michael RSC Adv Chemistry A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared via the previously known protocols, as 2-aminofuran derivatives were produced instead. The Royal Society of Chemistry 2021-04-30 /pmc/articles/PMC9032200/ /pubmed/35479147 http://dx.doi.org/10.1039/d1ra02279b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Aksenov, Nicolai A.
Aksenov, Dmitrii A.
Kurenkov, Igor A.
Aksenov, Alexander V.
Skomorokhov, Anton A.
Prityko, Lidiya A.
Rubin, Michael
Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones
title Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones
title_full Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones
title_fullStr Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones
title_full_unstemmed Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones
title_short Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones
title_sort preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2h-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032200/
https://www.ncbi.nlm.nih.gov/pubmed/35479147
http://dx.doi.org/10.1039/d1ra02279b
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