Development and Evolution of DNA-Dependent Protein Kinase Inhibitors toward Cancer Therapy

DNA double-strand break (DSB) is considered the most deleterious type of DNA damage, which is generated by ionizing radiation (IR) and a subset of anticancer drugs. DNA-dependent protein kinase (DNA-PK), which is composed of a DNA-PK catalytic subunit (DNA-PKcs) and Ku80-Ku70 heterodimer, acts as th...

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Detalles Bibliográficos
Autor principal: Matsumoto, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032228/
https://www.ncbi.nlm.nih.gov/pubmed/35457081
http://dx.doi.org/10.3390/ijms23084264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032228/
https://www.ncbi.nlm.nih.gov/pubmed/35457081
http://dx.doi.org/10.3390/ijms23084264

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