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The Development of the Davis Food Glycopedia—A Glycan Encyclopedia of Food

The molecular complexity of the carbohydrates consumed by humans has been deceptively oversimplified due to a lack of analytical methods that possess the throughput, sensitivity, and resolution required to provide quantitative structural information. However, such information is becoming an integral...

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Autores principales: Castillo, Juan J., Couture, Garret, Bacalzo, Nikita P., Chen, Ye, Chin, Elizabeth L., Blecksmith, Sarah E., Bouzid, Yasmine Y., Vainberg, Yael, Masarweh, Chad, Zhou, Qingwen, Smilowitz, Jennifer T., German, J. Bruce, Mills, David A., Lemay, Danielle G., Lebrilla, Carlito B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032246/
https://www.ncbi.nlm.nih.gov/pubmed/35458202
http://dx.doi.org/10.3390/nu14081639
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author Castillo, Juan J.
Couture, Garret
Bacalzo, Nikita P.
Chen, Ye
Chin, Elizabeth L.
Blecksmith, Sarah E.
Bouzid, Yasmine Y.
Vainberg, Yael
Masarweh, Chad
Zhou, Qingwen
Smilowitz, Jennifer T.
German, J. Bruce
Mills, David A.
Lemay, Danielle G.
Lebrilla, Carlito B.
author_facet Castillo, Juan J.
Couture, Garret
Bacalzo, Nikita P.
Chen, Ye
Chin, Elizabeth L.
Blecksmith, Sarah E.
Bouzid, Yasmine Y.
Vainberg, Yael
Masarweh, Chad
Zhou, Qingwen
Smilowitz, Jennifer T.
German, J. Bruce
Mills, David A.
Lemay, Danielle G.
Lebrilla, Carlito B.
author_sort Castillo, Juan J.
collection PubMed
description The molecular complexity of the carbohydrates consumed by humans has been deceptively oversimplified due to a lack of analytical methods that possess the throughput, sensitivity, and resolution required to provide quantitative structural information. However, such information is becoming an integral part of understanding how specific glycan structures impact health through their interaction with the gut microbiome and host physiology. This work presents a detailed catalogue of the glycans present in complementary foods commonly consumed by toddlers during weaning and foods commonly consumed by American adults. The monosaccharide compositions of over 800 foods from diverse food groups including Fruits, Vegetables, Grain Products, Beans, Peas, Other Legumes, Nuts, Seeds; Sugars, Sweets and Beverages; Animal Products, and more were obtained and used to construct the “Davis Food Glycopedia” (DFG), an open-access database that provides quantitative structural information on the carbohydrates in food. While many foods within the same group possessed similar compositions, hierarchical clustering analysis revealed similarities between different groups as well. Such a Glycopedia can be used to formulate diets rich in specific monosaccharide residues to provide a more targeted modulation of the gut microbiome, thereby opening the door for a new class of prophylactic or therapeutic diets.
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spelling pubmed-90322462022-04-23 The Development of the Davis Food Glycopedia—A Glycan Encyclopedia of Food Castillo, Juan J. Couture, Garret Bacalzo, Nikita P. Chen, Ye Chin, Elizabeth L. Blecksmith, Sarah E. Bouzid, Yasmine Y. Vainberg, Yael Masarweh, Chad Zhou, Qingwen Smilowitz, Jennifer T. German, J. Bruce Mills, David A. Lemay, Danielle G. Lebrilla, Carlito B. Nutrients Article The molecular complexity of the carbohydrates consumed by humans has been deceptively oversimplified due to a lack of analytical methods that possess the throughput, sensitivity, and resolution required to provide quantitative structural information. However, such information is becoming an integral part of understanding how specific glycan structures impact health through their interaction with the gut microbiome and host physiology. This work presents a detailed catalogue of the glycans present in complementary foods commonly consumed by toddlers during weaning and foods commonly consumed by American adults. The monosaccharide compositions of over 800 foods from diverse food groups including Fruits, Vegetables, Grain Products, Beans, Peas, Other Legumes, Nuts, Seeds; Sugars, Sweets and Beverages; Animal Products, and more were obtained and used to construct the “Davis Food Glycopedia” (DFG), an open-access database that provides quantitative structural information on the carbohydrates in food. While many foods within the same group possessed similar compositions, hierarchical clustering analysis revealed similarities between different groups as well. Such a Glycopedia can be used to formulate diets rich in specific monosaccharide residues to provide a more targeted modulation of the gut microbiome, thereby opening the door for a new class of prophylactic or therapeutic diets. MDPI 2022-04-14 /pmc/articles/PMC9032246/ /pubmed/35458202 http://dx.doi.org/10.3390/nu14081639 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Castillo, Juan J.
Couture, Garret
Bacalzo, Nikita P.
Chen, Ye
Chin, Elizabeth L.
Blecksmith, Sarah E.
Bouzid, Yasmine Y.
Vainberg, Yael
Masarweh, Chad
Zhou, Qingwen
Smilowitz, Jennifer T.
German, J. Bruce
Mills, David A.
Lemay, Danielle G.
Lebrilla, Carlito B.
The Development of the Davis Food Glycopedia—A Glycan Encyclopedia of Food
title The Development of the Davis Food Glycopedia—A Glycan Encyclopedia of Food
title_full The Development of the Davis Food Glycopedia—A Glycan Encyclopedia of Food
title_fullStr The Development of the Davis Food Glycopedia—A Glycan Encyclopedia of Food
title_full_unstemmed The Development of the Davis Food Glycopedia—A Glycan Encyclopedia of Food
title_short The Development of the Davis Food Glycopedia—A Glycan Encyclopedia of Food
title_sort development of the davis food glycopedia—a glycan encyclopedia of food
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032246/
https://www.ncbi.nlm.nih.gov/pubmed/35458202
http://dx.doi.org/10.3390/nu14081639
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