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Bacteroides fragilis Toxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 by the E-Cadherin/β-Catenin/NF-κB Dependent Pathway

Enterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that can promote colitis associated cancer in humans. ETBF secretes the metalloprotease, B. fragilis toxin (BFT), which can induce ectodomain cleavage of E-cadherin and IL-8 secretion through the β-catenin, NF-κB, a...

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Detalles Bibliográficos
Autores principales: Lee, Chang-Gun, Hwang, Soonjae, Gwon, Sun-Yeong, Park, Chanoh, Jo, Minjeong, Hong, Ju-Eun, Rhee, Ki-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032310/
https://www.ncbi.nlm.nih.gov/pubmed/35453577
http://dx.doi.org/10.3390/biomedicines10040827