Experimental and Computational Structural Studies of 2,3,5-Trisubstituted and 1,2,3,5-Tetrasubstituted Indoles as Non-Competitive Antagonists of GluK1/GluK2 Receptors

The blockade of kainate receptors, in particular with non-competitive antagonists, has—due to their anticonvulsant and neuroprotective properties—therapeutic potential in many central nervous system (CNS) diseases. Deciphering the structural properties of kainate receptor ligands is crucial to desig...

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Detalles Bibliográficos
Autores principales: Bartyzel, Agata, Kaczor, Agnieszka A., Mahmoudi, Ghodrat, Masoudiasl, Ardavan, Wróbel, Tomasz M., Pitucha, Monika, Matosiuk, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032324/
https://www.ncbi.nlm.nih.gov/pubmed/35458681
http://dx.doi.org/10.3390/molecules27082479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032324/
https://www.ncbi.nlm.nih.gov/pubmed/35458681
http://dx.doi.org/10.3390/molecules27082479

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