Cargando…

Experimental and Computational Structural Studies of 2,3,5-Trisubstituted and 1,2,3,5-Tetrasubstituted Indoles as Non-Competitive Antagonists of GluK1/GluK2 Receptors

The blockade of kainate receptors, in particular with non-competitive antagonists, has—due to their anticonvulsant and neuroprotective properties—therapeutic potential in many central nervous system (CNS) diseases. Deciphering the structural properties of kainate receptor ligands is crucial to desig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bartyzel, Agata, Kaczor, Agnieszka A., Mahmoudi, Ghodrat, Masoudiasl, Ardavan, Wróbel, Tomasz M., Pitucha, Monika, Matosiuk, Dariusz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032324/ https://www.ncbi.nlm.nih.gov/pubmed/35458681 http://dx.doi.org/10.3390/molecules27082479

Ejemplares similares

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3
por: Pigoni, Martina, et al.
Publicado: (2020)

Synthesis and molecular docking of novel non-competitive antagonists of GluK2 receptor
por: Kaczor, Agnieszka A., et al.
Publicado: (2014)

Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor
por: Khanra, Nandish, et al.
Publicado: (2021)

Parkin regulates kainate receptors by interacting with the GluK2 subunit
por: Maraschi, AnnaMaria, et al.
Publicado: (2014)

GluK2-Mediated Excitability within the Superficial Layers of the Entorhinal Cortex
por: Beed, Prateep S., et al.
Publicado: (2009)

Correlating efficacy and desensitization with GluK2 ligand-binding domain movements
por: Nayeem, Naushaba, et al.
Publicado: (2013)

Correction: GluK2-Mediated Excitability within the Superficial Layers of the Entorhinal Cortex
por: Beed, Prateep S., et al.
Publicado: (2009)

SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity
por: Chamberlain, Sophie E L, et al.
Publicado: (2012)

Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors
por: Gonzalez, Cuauhtemoc U., et al.
Publicado: (2021)

Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery
por: Kumari, Jyoti, et al.
Publicado: (2019)

Modification and movement: Phosphorylation and SUMOylation regulate endocytosis of GluK2-containing kainate receptors
por: Wilkinson, Kevin A., et al.
Publicado: (2012)

The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines
por: Kesaf, Sebnem, et al.
Publicado: (2020)

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype
por: Chałupnik, Paulina, et al.
Publicado: (2022)

Fatty acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesis
por: Wilding, Timothy J., et al.
Publicado: (2010)

Molecular Dynamics Investigation of gluazo, a Photo-Switchable Ligand for the Glutamate Receptor GluK2
por: Guo, Yanan, et al.
Publicado: (2015)

The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging
por: Abarkan, Myriam, et al.
Publicado: (2019)

Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel
por: Gangwar, Shanti Pal, et al.
Publicado: (2023)

Expression of GluK1c underlies the developmental switch in presynaptic kainate receptor function
por: Vesikansa, Aino, et al.
Publicado: (2012)

Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing
por: Wilding, Timothy J., et al.
Publicado: (2019)

Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1
por: Sheng, Nengyin, et al.
Publicado: (2015)

Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus
por: Ojanen, Simo, et al.
Publicado: (2023)

GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors
por: Nair, Jithin D., et al.
Publicado: (2023)

Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain
por: Duan, Gui-Fang, et al.
Publicado: (2018)

Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina
por: Haumann, Iris, et al.
Publicado: (2017)

Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles
por: Lopez, Melany N., et al.
Publicado: (2013)

A Study of GluK1 Kainate Receptor Polymorphisms in Down Syndrome Reveals Allelic Non-Disjunction at 1173(C/T)
por: Ghosh, Debarati, et al.
Publicado: (2009)

Discerning non-disjunction in Down syndrome patients by means of GluK1-(AGAT)(n) and D21S2055-(GATA)(n) microsatellites on chromosome 21
por: Ghosh, Debarati, et al.
Publicado: (2012)

Transcriptomic and Phenotypic Analysis of CRISPR/Cas9-Mediated gluk2 Knockout in Zebrafish
por: Yan, Qianqian, et al.
Publicado: (2022)

Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D(2) Receptor Ligand
por: Kondej, Magda, et al.
Publicado: (2018)

Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
por: Wang, Xinwei, et al.
Publicado: (2023)

Molecular and pharmacological evidence for a facilitatory functional role of pre-synaptic GLUK2/3 kainate receptors on GABA release in rat trigeminal caudal nucleus
por: Samengo, I, et al.
Publicado: (2012)

An efficient multicomponent synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed by a magnetic nanoparticle supported Lewis acidic deep eutectic solvent
por: Nguyen, Thanh Thi, et al.
Publicado: (2019)

Abnormal Glu/mGluR(2/3)/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression
por: Liu, Jian, et al.
Publicado: (2020)

The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency
por: Kammermeier, Paul J
Publicado: (2012)

The Role of GLU(K5)-Containing Kainate Receptors in Entorhinal Cortex Gamma Frequency Oscillations
por: Stanger, Heather L., et al.
Publicado: (2008)

Correction: An efficient multicomponent synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed by a magnetic nanoparticle supported Lewis acidic deep eutectic solvent
por: Nguyen, Thanh Thi, et al.
Publicado: (2020)

GluR2(Q) and GluR2(R) AMPA Subunits are not Targets of lypd2 Interaction
por: Lauriello, Anna, et al.
Publicado: (2022)

Functional assessment of the NMDA receptor variant GluN2A (R586K)
por: Marwick, Katie F.M., et al.
Publicado: (2017)

Disruption of cerebellar microzonal organization in GluD2 (GluRδ2) knockout mouse
por: Hashizume, Miki, et al.
Publicado: (2013)

1,2,3,5-Tetrahydronaphtho[2,1-c]oxepine
por: Lough, Alan J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rnt1abu504djgvubicikueu0ra