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Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women

The evidence as to whether caffeine consumption is beneficial or harmful to human health has been mixed. This study aimed to examine the effect of 25-hydroxyvitamin D (25(OH)D) concentration on the association between caffeine consumption and mineral metabolism in pregnant women. This is a cross-sec...

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Autores principales: Tung, Keith T. S., Wong, Rosa S., Cheung, Calvin K. M., Ko, Jennifer K. Y., Chan, Bianca N. K., Lee, Albert, So, Hung-Kwan, Wong, Wilfred H. S., Leung, Wing-Cheong, Ip, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032703/
https://www.ncbi.nlm.nih.gov/pubmed/35458179
http://dx.doi.org/10.3390/nu14081616
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author Tung, Keith T. S.
Wong, Rosa S.
Cheung, Calvin K. M.
Ko, Jennifer K. Y.
Chan, Bianca N. K.
Lee, Albert
So, Hung-Kwan
Wong, Wilfred H. S.
Leung, Wing-Cheong
Ip, Patrick
author_facet Tung, Keith T. S.
Wong, Rosa S.
Cheung, Calvin K. M.
Ko, Jennifer K. Y.
Chan, Bianca N. K.
Lee, Albert
So, Hung-Kwan
Wong, Wilfred H. S.
Leung, Wing-Cheong
Ip, Patrick
author_sort Tung, Keith T. S.
collection PubMed
description The evidence as to whether caffeine consumption is beneficial or harmful to human health has been mixed. This study aimed to examine the effect of 25-hydroxyvitamin D (25(OH)D) concentration on the association between caffeine consumption and mineral metabolism in pregnant women. This is a cross-sectional study involving pregnant women at their 25th to 35th gestational week recruited at antenatal clinics in the period of July 2019 to December 2020. Peripheral blood samples were collected to determine their total 25(OH)D, albumin, alkaline phosphatase (ALP), calcium, phosphate, and ferritin level in serum. Questionnaires on demographics and dietary intake were also administered. Among 181 pregnant women recruited (Average age = 32.9 years), 50 (27.6%) of them were found to be vitamin D insufficient (25(OH)D concentration < 75 nmol/L), and 131 (72.4%) were vitamin D sufficient (25(OH)D concentration ≥ 75 nmol/L). Adjusted regression models identified an association between higher caffeine intake and lower ALP level only among vitamin D-sufficient pregnant women (β = −0.24, p = 0.006), but not in those with insufficient vitamin D (β = −0.02, p = 0.912). The findings provide new insights into 25(OH)D concentration as a potential modifier of the health effects of caffeine consumption during pregnancy.
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spelling pubmed-90327032022-04-23 Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women Tung, Keith T. S. Wong, Rosa S. Cheung, Calvin K. M. Ko, Jennifer K. Y. Chan, Bianca N. K. Lee, Albert So, Hung-Kwan Wong, Wilfred H. S. Leung, Wing-Cheong Ip, Patrick Nutrients Article The evidence as to whether caffeine consumption is beneficial or harmful to human health has been mixed. This study aimed to examine the effect of 25-hydroxyvitamin D (25(OH)D) concentration on the association between caffeine consumption and mineral metabolism in pregnant women. This is a cross-sectional study involving pregnant women at their 25th to 35th gestational week recruited at antenatal clinics in the period of July 2019 to December 2020. Peripheral blood samples were collected to determine their total 25(OH)D, albumin, alkaline phosphatase (ALP), calcium, phosphate, and ferritin level in serum. Questionnaires on demographics and dietary intake were also administered. Among 181 pregnant women recruited (Average age = 32.9 years), 50 (27.6%) of them were found to be vitamin D insufficient (25(OH)D concentration < 75 nmol/L), and 131 (72.4%) were vitamin D sufficient (25(OH)D concentration ≥ 75 nmol/L). Adjusted regression models identified an association between higher caffeine intake and lower ALP level only among vitamin D-sufficient pregnant women (β = −0.24, p = 0.006), but not in those with insufficient vitamin D (β = −0.02, p = 0.912). The findings provide new insights into 25(OH)D concentration as a potential modifier of the health effects of caffeine consumption during pregnancy. MDPI 2022-04-13 /pmc/articles/PMC9032703/ /pubmed/35458179 http://dx.doi.org/10.3390/nu14081616 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tung, Keith T. S.
Wong, Rosa S.
Cheung, Calvin K. M.
Ko, Jennifer K. Y.
Chan, Bianca N. K.
Lee, Albert
So, Hung-Kwan
Wong, Wilfred H. S.
Leung, Wing-Cheong
Ip, Patrick
Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women
title Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women
title_full Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women
title_fullStr Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women
title_full_unstemmed Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women
title_short Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women
title_sort total 25(oh)d concentration moderates the association between caffeine consumption and the alkaline phosphatase level in pregnant women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032703/
https://www.ncbi.nlm.nih.gov/pubmed/35458179
http://dx.doi.org/10.3390/nu14081616
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