Propofol, an Anesthetic Agent, Inhibits HCN Channels through the Allosteric Modulation of the cAMP-Dependent Gating Mechanism

Propofol is a broadly used intravenous anesthetic agent that can cause cardiovascular effects, including bradycardia and asystole. A possible mechanism for these effects is slowing cardiac pacemaker activity due to inhibition of the hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimizu, Morihiro, Mi, Xinya, Toyoda, Futoshi, Kojima, Akiko, Ding, Wei-Guang, Fukushima, Yutaka, Omatsu-Kanbe, Mariko, Kitagawa, Hirotoshi, Matsuura, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032835/
https://www.ncbi.nlm.nih.gov/pubmed/35454159
http://dx.doi.org/10.3390/biom12040570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032835/
https://www.ncbi.nlm.nih.gov/pubmed/35454159
http://dx.doi.org/10.3390/biom12040570

Ejemplares similares