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Propofol, an Anesthetic Agent, Inhibits HCN Channels through the Allosteric Modulation of the cAMP-Dependent Gating Mechanism

Propofol is a broadly used intravenous anesthetic agent that can cause cardiovascular effects, including bradycardia and asystole. A possible mechanism for these effects is slowing cardiac pacemaker activity due to inhibition of the hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels...

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Detalles Bibliográficos
Autores principales:	Shimizu, Morihiro, Mi, Xinya, Toyoda, Futoshi, Kojima, Akiko, Ding, Wei-Guang, Fukushima, Yutaka, Omatsu-Kanbe, Mariko, Kitagawa, Hirotoshi, Matsuura, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032835/ https://www.ncbi.nlm.nih.gov/pubmed/35454159 http://dx.doi.org/10.3390/biom12040570

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