Access to 3,3-disubstituted oxindoles via microwave-assisted Cannizzaro and aldol reactions of formaldehyde with isatins and their imines

3,3-Disubstituted oxindoles are important structure motifs in natural products and pharmaceutical agents. Here we disclose a simple and direct access to this class of molecules by using readily available formaldehyde and isatins (and their imines) as the substrates. The reaction proceeds with the as...

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Detalles Bibliográficos
Autores principales: Huang, Xuan, Wang, Hongling, Cao, Qingxiang, Li, Yong, Zhang, Junmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033177/
https://www.ncbi.nlm.nih.gov/pubmed/35479673
http://dx.doi.org/10.1039/d1ra02150h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033177/
https://www.ncbi.nlm.nih.gov/pubmed/35479673
http://dx.doi.org/10.1039/d1ra02150h

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