Rational structural modification of the isatin scaffold to develop new and potent antimicrobial agents targeting bacterial peptidoglycan glycosyltransferase

A series of isatin derivatives bearing three different substituent groups at the N-1, C-3 and C-5 positions of the isatin scaffold were systematically designed and synthesized to study the structure–activity relationship of their inhibition of bacterial peptidoglycan glycosyltransferase (PGT) activi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yong, Liang, Zhiguang, Zheng, Yuanyuan, Leung, Alan Siu-Lun, Yan, Siu-Cheong, So, Pui-Kin, Leung, Yun-Chung, Wong, Wing-Leung, Wong, Kwok-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033243/
https://www.ncbi.nlm.nih.gov/pubmed/35480164
http://dx.doi.org/10.1039/d1ra02119b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033243/
https://www.ncbi.nlm.nih.gov/pubmed/35480164
http://dx.doi.org/10.1039/d1ra02119b

Ejemplares similares