Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

Single nucleotide variants (SNVs) are prevalent genetic factors shaping individual trait profiles and disease susceptibility. The recent development and optimizations of base editors, rubber and pencil genome editing tools now promise to enable direct functional assessment of SNVs in model organisms...

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Detalles Bibliográficos
Autores principales: Cornean, Alex, Gierten, Jakob, Welz, Bettina, Mateo, Juan Luis, Thumberger, Thomas, Wittbrodt, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033269/
https://www.ncbi.nlm.nih.gov/pubmed/35373735
http://dx.doi.org/10.7554/eLife.72124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033269/
https://www.ncbi.nlm.nih.gov/pubmed/35373735
http://dx.doi.org/10.7554/eLife.72124

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