A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation

Degradation by the 26 S proteasome is an intricately regulated process fine tuned by the precise nature of ubiquitin modifications attached to a protein substrate. By debranching ubiquitin chains composed of K48 linkages, the proteasome-associated ubiquitin C-terminal hydrolase UCHL5/UCH37 serves as...

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Detalles Bibliográficos
Autores principales: Du, Jiale, Babik, Sandor, Li, Yanfeng, Deol, Kirandeep K, Eyles, Stephen J, Fejzo, Jasna, Tonelli, Marco, Strieter, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033301/
https://www.ncbi.nlm.nih.gov/pubmed/35451368
http://dx.doi.org/10.7554/eLife.76100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033301/
https://www.ncbi.nlm.nih.gov/pubmed/35451368
http://dx.doi.org/10.7554/eLife.76100

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