Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles

In this work, phosphorylated lipid-conjugated oligonucleotide (DNA-lipid-P) has been synthesized to develop an enzyme-responsive self-assembly of DNA amphiphiles based on dephosphorylation-induced increase of hydrophobicity. Since elevated ALP level is a critical index in some diseases, ALP-triggere...

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Detalles Bibliográficos
Autores principales: Zou, Jianmei, Gao, Qian, Nie, Jinfang, Zhang, Yun, Jin, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033439/
https://www.ncbi.nlm.nih.gov/pubmed/35480953
http://dx.doi.org/10.1039/d1ra01668g
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author Zou, Jianmei
Gao, Qian
Nie, Jinfang
Zhang, Yun
Jin, Cheng
author_facet Zou, Jianmei
Gao, Qian
Nie, Jinfang
Zhang, Yun
Jin, Cheng
author_sort Zou, Jianmei
collection PubMed
description In this work, phosphorylated lipid-conjugated oligonucleotide (DNA-lipid-P) has been synthesized to develop an enzyme-responsive self-assembly of DNA amphiphiles based on dephosphorylation-induced increase of hydrophobicity. Since elevated ALP level is a critical index in some diseases, ALP-triggered self-assembly of DNA amphiphiles shows promise in disease diagnosis and cancer treatment.
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spelling pubmed-90334392022-04-26 Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles Zou, Jianmei Gao, Qian Nie, Jinfang Zhang, Yun Jin, Cheng RSC Adv Chemistry In this work, phosphorylated lipid-conjugated oligonucleotide (DNA-lipid-P) has been synthesized to develop an enzyme-responsive self-assembly of DNA amphiphiles based on dephosphorylation-induced increase of hydrophobicity. Since elevated ALP level is a critical index in some diseases, ALP-triggered self-assembly of DNA amphiphiles shows promise in disease diagnosis and cancer treatment. The Royal Society of Chemistry 2021-05-21 /pmc/articles/PMC9033439/ /pubmed/35480953 http://dx.doi.org/10.1039/d1ra01668g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zou, Jianmei
Gao, Qian
Nie, Jinfang
Zhang, Yun
Jin, Cheng
Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles
title Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles
title_full Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles
title_fullStr Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles
title_full_unstemmed Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles
title_short Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles
title_sort enzymatic dephosphorylation-triggered self-assembly of dna amphiphiles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033439/
https://www.ncbi.nlm.nih.gov/pubmed/35480953
http://dx.doi.org/10.1039/d1ra01668g
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