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Synthesis of tetrahydro-β-carbolines from 2-indolylmethyl azides and propargylic alcohols

A facile and efficient route to tetrahydro-β-carbolines from 2-indolylmethyl azides and propargylic alcohols via acid-catalyzed dehydrative annulation reactions is described. This reaction proceeds through a cascade sequence of Friedel–Crafts-type alkylation followed by intramolecular “Click” reacti...

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Detalles Bibliográficos
Autores principales: Yin, Haiting, Ma, Qin, Wang, Yushan, Gu, Xiaoxia, Feng, Zhijun, Wu, Yunjun, Wang, Ming, Wang, Shaoyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033608/
https://www.ncbi.nlm.nih.gov/pubmed/35479240
http://dx.doi.org/10.1039/d1ra03022a