Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design

Microtubules consisting of α- and β-tubulin heterodimers have proven to be an efficient drug target for cancer therapy. A broad range of agents, including ELR510444 and parbendazole, can bind to tubulin and interfere with microtubule assembly. ELR510444 and parbendazole are colchicine binding site i...

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Detalles Bibliográficos
Autores principales: Lei, Jia-Hong, Ma, Ling-Ling, Xian, Jing-Hong, Chen, Hai, Zhou, Jian-Jian, Chen, Hao, Lei, Qian, Li, Yu-Yan, Wang, Yan-Yan, Wang, Yu-Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033620/
https://www.ncbi.nlm.nih.gov/pubmed/35478655
http://dx.doi.org/10.1039/d1ra01173a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033620/
https://www.ncbi.nlm.nih.gov/pubmed/35478655
http://dx.doi.org/10.1039/d1ra01173a

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