Copper-catalyzed thioketalization of enones featuring trifluoromethyl groups

Synthetic methods for the preparation of thioketals featuring CF(3) groups are rare. Here, we have developed a copper-catalyzed thioketalization of enones bearing CF(3) groups and various mercaptans. 24 thioketal molecules have been obtained with moderate to excellent yield. Meanwhile, a preparative scale experiment has been performed giving over 95% yield. This work allows the straightforward formation of thioketals containing CF(3) groups and unsaturated double bonds.