Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Preneoplastic mammary tissues from human female BRCA1 mutation carriers, or Brca1-mutant mice, display unexplained abnormalities in luminal differentiation. We now study the division characteristics of human mammary cells purified from female BRCA1 mutation carriers or non-carrier donors. We show pr...

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Detalles Bibliográficos
Autores principales: He, Zhengcheng, Ghorayeb, Ryan, Tan, Susanna, Chen, Ke, Lorentzian, Amanda C., Bottyan, Jack, Aalam, Syed Mohammed Musheer, Pujana, Miguel Angel, Lange, Philipp F., Kannan, Nagarajan, Eaves, Connie J., Maxwell, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033786/
https://www.ncbi.nlm.nih.gov/pubmed/35459234
http://dx.doi.org/10.1038/s41467-022-29885-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033786/
https://www.ncbi.nlm.nih.gov/pubmed/35459234
http://dx.doi.org/10.1038/s41467-022-29885-2

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