HDAC6 regulates NF-κB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression

Elevated pro-inflammatory signalling coupled with catabolic metalloproteinase expression is a common feature of arthritis, leading to cartilage damage, deterioration of the joint architecture and the associated pain and immobility. Countering these processes, histone deacetylase inhibitors (HDACi) h...

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Detalles Bibliográficos
Autores principales: Barter, Matt J., Butcher, Andrew, Wang, Hui, Tsompani, Dimitra, Galler, Martin, Rumsby, Ellen L., Culley, Kirsty L., Clark, Ian M., Young, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033835/
https://www.ncbi.nlm.nih.gov/pubmed/35459919
http://dx.doi.org/10.1038/s41598-022-10518-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033835/
https://www.ncbi.nlm.nih.gov/pubmed/35459919
http://dx.doi.org/10.1038/s41598-022-10518-z

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