Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine derivatives as potent fibroblast growth factor receptor inhibitors

Abnormal activation of FGFR signaling pathway plays an essential role in various types of tumors. Therefore, targeting FGFRs represents an attractive strategy for cancer therapy. Herein, we report a series of 1H-pyrrolo[2,3-b]pyridine derivatives with potent activities against FGFR1, 2, and 3. Among...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Xingping, Liu, Zhihao, Yue, Lin, Wu, Xiuli, Wei, Wei, Que, Hanyun, Ye, Tinghong, Luo, Yi, Zhang, Yiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033946/
https://www.ncbi.nlm.nih.gov/pubmed/35479379
http://dx.doi.org/10.1039/d1ra02660g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033946/
https://www.ncbi.nlm.nih.gov/pubmed/35479379
http://dx.doi.org/10.1039/d1ra02660g

Ejemplares similares