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Methionine epimerization in cyclic peptides

Bioactive flax cyclic octa- and nona-peptides containing single methionine (Met) and its oxidized forms were treated under mild alkaline conditions to perform regio-selective epimerization. Cyclic peptide epimerization at the Met α-proton in a single chemical step has not been reported previously. T...

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Detalles Bibliográficos
Autores principales: Jadhav, Pramodkumar D., Shen, Jianheng, Burnett, Peta-Gaye, Yang, Jian, Sammynaiken, Ramaswami, Reaney, Martin J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034004/
https://www.ncbi.nlm.nih.gov/pubmed/35479339
http://dx.doi.org/10.1039/d1ra04260b