Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90

Enzymes within the de novo purine biosynthetic pathway spatially organize into dynamic intracellular assemblies called purinosomes. The formation of purinosomes has been correlated with growth conditions resulting in high purine demand, and therefore, the cellular advantage of complexation has been...

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Detalles Bibliográficos
Autores principales: Pedley, Anthony M., Boylan, Jack P., Chan, Chung Yu, Kennedy, Erin L., Kyoung, Minjoung, Benkovic, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034097/
https://www.ncbi.nlm.nih.gov/pubmed/35307352
http://dx.doi.org/10.1016/j.jbc.2022.101845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034097/
https://www.ncbi.nlm.nih.gov/pubmed/35307352
http://dx.doi.org/10.1016/j.jbc.2022.101845

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