Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition

Glycation is a nonenzymatic posttranslational modification (PTM) known to be increased in the brains of hyperglycemic patients. Alpha-synuclein (αSN), a central player in the etiology of Parkinson’s disease, can be glycated at lysine residues, thereby reducing αSN fibril formation in vitro and modul...

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Detalles Bibliográficos
Autores principales: Farzadfard, Azad, König, Annekatrin, Petersen, Steen Vang, Nielsen, Janni, Vasili, Eftychia, Dominguez-Meijide, Antonio, Buell, Alexander K., Outeiro, Tiago Fleming, Otzen, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034100/
https://www.ncbi.nlm.nih.gov/pubmed/35314196
http://dx.doi.org/10.1016/j.jbc.2022.101848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034100/
https://www.ncbi.nlm.nih.gov/pubmed/35314196
http://dx.doi.org/10.1016/j.jbc.2022.101848

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