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Water-promoted dehydrative coupling of 2-aminopyridines in heptane via a borrowing hydrogen strategy

A synthetic method for dehydrative N-benzylation promoted by water molecules in heptane using a π-benzylpalladium system has been developed. The presence of water significantly accelerates carbon–nitrogen bond formation, which is accomplished in an atom-economical process to afford the corresponding...

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Detalles Bibliográficos
Autores principales: Nakayama, Taku, Hikawa, Hidemasa, Kikkawa, Shoko, Azumaya, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034306/
https://www.ncbi.nlm.nih.gov/pubmed/35480450
http://dx.doi.org/10.1039/d1ra04118e