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Artifactual FA dimers mimic FAHFA signals in untargeted metabolomics pipelines

FA esters of hydroxy FAs (FAHFAs) are lipokines with extensive structural and regional isomeric diversity that impact multiple physiological functions, including insulin sensitivity and glucose homeostasis. Because of their low molar abundance, FAHFAs are typically quantified using highly sensitive...

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Detalles Bibliográficos
Autores principales: Nelson, Alisa B., Chow, Lisa S., Hughey, Curtis C., Crawford, Peter A., Puchalska, Patrycja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034316/
https://www.ncbi.nlm.nih.gov/pubmed/35315332
http://dx.doi.org/10.1016/j.jlr.2022.100201