Sparse dictionary learning recovers pleiotropy from human cell fitness screens

In high-throughput functional genomic screens, each gene product is commonly assumed to exhibit a singular biological function within a defined protein complex or pathway. In practice, a single gene perturbation may induce multiple cascading functional outcomes, a genetic principle known as pleiotro...

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Detalles Bibliográficos
Autores principales: Pan, Joshua, Kwon, Jason J., Talamas, Jessica A., Borah, Ashir A., Vazquez, Francisca, Boehm, Jesse S., Tsherniak, Aviad, Zitnik, Marinka, McFarland, James M., Hahn, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035054/
https://www.ncbi.nlm.nih.gov/pubmed/35085500
http://dx.doi.org/10.1016/j.cels.2021.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035054/
https://www.ncbi.nlm.nih.gov/pubmed/35085500
http://dx.doi.org/10.1016/j.cels.2021.12.005

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