Cargando…
Sparse dictionary learning recovers pleiotropy from human cell fitness screens
In high-throughput functional genomic screens, each gene product is commonly assumed to exhibit a singular biological function within a defined protein complex or pathway. In practice, a single gene perturbation may induce multiple cascading functional outcomes, a genetic principle known as pleiotro...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035054/ https://www.ncbi.nlm.nih.gov/pubmed/35085500 http://dx.doi.org/10.1016/j.cels.2021.12.005 |