Cargando…
Human clinical mutations in mitochondrially encoded subunits of Complex I can be successfully modeled in E. coli
Respiratory Complex I is the site of a large fraction of the mutations that appear to cause mitochondrial disease. Seven of its subunits are mitochondrially encoded, and therefore, such mutants are particularly difficult to construct in cell-culture model systems. We have selected 13 human clinical...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035099/ https://www.ncbi.nlm.nih.gov/pubmed/35306226 http://dx.doi.org/10.1016/j.mito.2022.03.001 |