Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function

Cancer cells secrete aberrantly large amounts of extracellular vesicles (EVs) including exosomes, which originate from multivesicular bodies (MVBs). Because EVs potentially contribute to tumor progression, EV inhibitors are of interest as novel therapeutics. We screened a fungal natural product libr...

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Detalles Bibliográficos
Autores principales: Mitani, Fumie, Lin, Jianyu, Sakamoto, Tatsuya, Uehara, Ryo, Hikita, Tomoya, Yoshida, Takuya, Setiawan, Andi, Arai, Masayoshi, Oneyama, Chitose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035176/
https://www.ncbi.nlm.nih.gov/pubmed/35461323
http://dx.doi.org/10.1038/s41598-022-10692-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035176/
https://www.ncbi.nlm.nih.gov/pubmed/35461323
http://dx.doi.org/10.1038/s41598-022-10692-0

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