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Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function
Cancer cells secrete aberrantly large amounts of extracellular vesicles (EVs) including exosomes, which originate from multivesicular bodies (MVBs). Because EVs potentially contribute to tumor progression, EV inhibitors are of interest as novel therapeutics. We screened a fungal natural product libr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035176/ https://www.ncbi.nlm.nih.gov/pubmed/35461323 http://dx.doi.org/10.1038/s41598-022-10692-0 |