A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer’s mouse model

The p75 neurotrophin receptor (p75(NTR)) is associated with multiple mechanisms linked to Alzheimer’s disease (AD); hence, modulating its function might confer therapeutic effects. In previous in vitro work, we developed small molecule p75(NTR) ligands that inhibited amyloid-β-induced degenerative s...

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Detalles Bibliográficos
Autores principales: Knowles, Juliet K., Simmons, Danielle A., Nguyen, Thuy-Vi V., Vander Griend, Lilith, Xie, Youmei, Zhang, Hong, Yang, Tao, Pollak, Julia, Chang, Timothy, Arancio, Ottavio, Buckwalter, Marion S., Wyss-Coray, Tony, Massa, Stephen M., Longo, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035212/
https://www.ncbi.nlm.nih.gov/pubmed/23545424
http://dx.doi.org/10.1016/j.neurobiolaging.2013.02.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035212/
https://www.ncbi.nlm.nih.gov/pubmed/23545424
http://dx.doi.org/10.1016/j.neurobiolaging.2013.02.015

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