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A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer’s mouse model

The p75 neurotrophin receptor (p75(NTR)) is associated with multiple mechanisms linked to Alzheimer’s disease (AD); hence, modulating its function might confer therapeutic effects. In previous in vitro work, we developed small molecule p75(NTR) ligands that inhibited amyloid-β-induced degenerative s...

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Detalles Bibliográficos
Autores principales:	Knowles, Juliet K., Simmons, Danielle A., Nguyen, Thuy-Vi V., Vander Griend, Lilith, Xie, Youmei, Zhang, Hong, Yang, Tao, Pollak, Julia, Chang, Timothy, Arancio, Ottavio, Buckwalter, Marion S., Wyss-Coray, Tony, Massa, Stephen M., Longo, Frank M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035212/ https://www.ncbi.nlm.nih.gov/pubmed/23545424 http://dx.doi.org/10.1016/j.neurobiolaging.2013.02.015

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