CRISPR-Cas9-mediated loss of function of β-catenin attenuates intervertebral disc degeneration

Intervertebral disc degeneration is a very common medical condition causing pain and disability, and it cannot be reversed by available treatment options. Here we report that targeting β-catenin, a pivotal factor associated with disc degeneration, ameliorates disc degeneration in a mouse model of di...

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Detalles Bibliográficos
Autores principales: Fan, Yunshan, Zhao, Lan, Lai, Yumei, Lu, Ke, Huang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035381/
https://www.ncbi.nlm.nih.gov/pubmed/35505959
http://dx.doi.org/10.1016/j.omtn.2022.03.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035381/
https://www.ncbi.nlm.nih.gov/pubmed/35505959
http://dx.doi.org/10.1016/j.omtn.2022.03.024

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