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Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules
ClpP is a highly conserved serine protease that is a critical enzyme in maintaining protein homeostasis and is an important drug target in pathogenic bacteria and various cancers. In its functional form, ClpP is a self-compartmentalizing protease composed of two stacked heptameric rings that allow p...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035409/ https://www.ncbi.nlm.nih.gov/pubmed/35245501 http://dx.doi.org/10.1016/j.jbc.2022.101781 |