Cargando…

Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules

ClpP is a highly conserved serine protease that is a critical enzyme in maintaining protein homeostasis and is an important drug target in pathogenic bacteria and various cancers. In its functional form, ClpP is a self-compartmentalizing protease composed of two stacked heptameric rings that allow p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mabanglo, Mark F., Houry, Walid A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	JBC Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035409/ https://www.ncbi.nlm.nih.gov/pubmed/35245501 http://dx.doi.org/10.1016/j.jbc.2022.101781

Ejemplares similares

Cellular functions of the ClpP protease impacting bacterial virulence
por: Aljghami, Mazen E., et al.
Publicado: (2022)

Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis
por: Bouchnak, Imen, et al.
Publicado: (2021)

ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores
por: Mabanglo, Mark F., et al.
Publicado: (2019)

ClpP Protease, a Promising Antimicrobial Target
por: Moreno-Cinos, Carlos, et al.
Publicado: (2019)

Insights to the Assembly of a Functionally Active Leptospiral ClpP1P2 Protease Complex along with Its ATPase Chaperone ClpX
por: Dhara, Anusua, et al.
Publicado: (2019)

Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2
por: Benaroudj, Nadia, et al.
Publicado: (2011)

Effects of ClpP protease on biofilm formation of Enterococcus faecalis
por: FENG, Ying, et al.
Publicado: (2021)

Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP
por: Fennell, Emily M. J., et al.
Publicado: (2022)

Bacterial ClpP Protease Is a Potential Target for Methyl Gallate
por: Zheng, Dehong, et al.
Publicado: (2021)

Structural insights of the p97/VCP AAA+ ATPase: How adapter interactions coordinate diverse cellular functionality
por: Braxton, Julian R., et al.
Publicado: (2023)

The Protein Chaperone ClpX Targets Native and Non-native Aggregated Substrates for Remodeling, Disassembly, and Degradation with ClpP
por: LaBreck, Christopher J., et al.
Publicado: (2017)

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
por: Felix, Jan, et al.
Publicado: (2019)

The ClpP Protease Is Required for the Stress Tolerance and Biofilm Formation in Actinobacillus pleuropneumoniae
por: Xie, Fang, et al.
Publicado: (2013)

The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1
por: Leodolter, Julia, et al.
Publicado: (2015)

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
por: Kirstein, Janine, et al.
Publicado: (2009)

Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities
por: Personne, Yoann, et al.
Publicado: (2013)

Correction: The ClpP Protease Is Required for the Stress Tolerance and Biofilm Formation in Actinobacillus pleuropneumoniae
por: Xie, Fang, et al.
Publicado: (2013)

Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
por: Nouri, Kazem, et al.
Publicado: (2020)

The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci
por: Pan, Stefan, et al.
Publicado: (2019)

Correction: The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1
Publicado: (2015)

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
por: Kim, Sora, et al.
Publicado: (2020)

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection
por: Raju, Ravikiran M., et al.
Publicado: (2012)

Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain
por: Fischer, Fabian, et al.
Publicado: (2013)

Open and compressed conformations of Francisella tularensis ClpP
por: Díaz‐Sáez, Laura, et al.
Publicado: (2016)

Generation of Lasso Peptide-Based ClpP Binders
por: Malik, Imran T., et al.
Publicado: (2021)

The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila
por: Li, Xiang-hui, et al.
Publicado: (2010)

Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues
por: Graves, Paul R., et al.
Publicado: (2019)

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity
por: Hu, Di, et al.
Publicado: (2019)

ClpP protease modulates bacterial growth, stress response, and bacterial virulence in Brucella abortus
por: Sun, Dongjie, et al.
Publicado: (2023)

Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis
por: Reinhardt, Laura, et al.
Publicado: (2022)

Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1–ClpP1P2 protease
por: Taylor, Gabrielle, et al.
Publicado: (2022)

Correction to “Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues”
por: Graves, Paul R., et al.
Publicado: (2022)

Insight into the RssB-Mediated Recognition and Delivery of σ(s) to the AAA+ Protease, ClpXP
por: Micevski, Dimce, et al.
Publicado: (2020)

Dual stoichiometry and subunit organization in the ClpP1/P2 protease from the cyanobacterium Synechococcus elongatus
por: Mikhailov, Victor A., et al.
Publicado: (2015)

Trigger Factor in Association with the ClpP1P2 Heterocomplex of Leptospira Promotes Protease/Peptidase Activity
por: Choudhury, Madhurima, et al.
Publicado: (2021)

Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development
por: Jacques, Samuel, et al.
Publicado: (2020)

A conserved strategy for structure change and energy transduction in Hsp104 and other AAA+ protein motors
por: Ye, Xiang, et al.
Publicado: (2021)

The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis
por: Azadmanesh, Jahaun, et al.
Publicado: (2022)

A Chicken Tapasin ortholog can chaperone empty HLA-B∗37:01 molecules independent of other peptide-loading components
por: Papadaki, Georgia F., et al.
Publicado: (2023)

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis
por: Guo, Chenxi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n19ojngvak4b5f3370seki9j6l