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Complement C1q in plasma induces nonspecific binding of poly(acrylic acid)-coated upconverting nanoparticle antibody conjugates

Upconverting nanoparticles are attractive reporters for immunoassays, because their high specific activity and lack of autofluorescence background enable their detection at extremely low concentrations. However, the sensitivity achieved with heterogeneous sandwich immunoassays using nanoparticle rep...

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Detalles Bibliográficos
Autores principales: Kuusinen, Saara, Ekman, Miikka, Raiko, Kirsti, Hannula, Heidi, Lyytikäinen, Annika, Lahtinen, Satu, Soukka, Tero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035425/
https://www.ncbi.nlm.nih.gov/pubmed/35332370
http://dx.doi.org/10.1007/s00216-022-04021-7