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Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes‐Associated Protein 1 Activation and Transient Expansion of Stem‐Like Cancer Cells

Induction of neoangiogenesis is a hallmark feature during disease progression of hepatocellular carcinoma (HCC). Antiangiogenetic compounds represent a mainstay of therapeutic approaches; however, development of chemoresistance is observed in the majority of patients. Recent findings suggest that tu...

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Detalles Bibliográficos
Autores principales: Castven, Darko, Czauderna, Carolin, Becker, Diana, Pereira, Sharon, Schmitt, Jennifer, Weinmann, Arndt, Shah, Viral, Hajduk, Jovana, Keggenhoff, Friederike, Binder, Harald, Keck, Tobias, Heilmann‐Heimbach, Stefanie, Wörns, Marcus A., Thorgeirsson, Snorri S., Breuhahn, Kai, Galle, Peter R., Marquardt, Jens U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035566/
https://www.ncbi.nlm.nih.gov/pubmed/34817932
http://dx.doi.org/10.1002/hep4.1869