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Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4(+) Th17 cells are considered pathogenic in MS and are harmful to OLs. We investigated the mechanisms driving human CD4(+) T cell-med...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035748/ https://www.ncbi.nlm.nih.gov/pubmed/35479072 http://dx.doi.org/10.3389/fimmu.2022.850616 |