Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4(+) Th17 cells are considered pathogenic in MS and are harmful to OLs. We investigated the mechanisms driving human CD4(+) T cell-med...

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Detalles Bibliográficos
Autores principales: Jamann, Hélène, Cui, Qiao-Ling, Desu, Haritha L., Pernin, Florian, Tastet, Olivier, Halaweh, Alexandre, Farzam-kia, Negar, Mamane, Victoria Hannah, Ouédraogo, Oumarou, Cleret-Buhot, Aurélie, Daigneault, Audrey, Balthazard, Renaud, Klement, Wendy, Lemaître, Florent, Arbour, Nathalie, Antel, Jack, Stratton, Jo Anne, Larochelle, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035748/
https://www.ncbi.nlm.nih.gov/pubmed/35479072
http://dx.doi.org/10.3389/fimmu.2022.850616

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