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Synthesis and Evaluation of a Non-Peptide Small-Molecule Drug Conjugate Targeting Integrin α(V)β(3)
An integrin α(V)β(3)-targeting linear RGD mimetic containing a small-molecule drug conjugate (SMDC) was synthesized by combining the antimitotic agent monomethyl auristatin E (MMAE), an enzymatically cleavable Val-Ala-PABC linker with a linear conjugable RGD mimetic. The structure proposal for the c...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035832/ https://www.ncbi.nlm.nih.gov/pubmed/35480387 http://dx.doi.org/10.3389/fchem.2022.869639 |