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Synthesis and Evaluation of a Non-Peptide Small-Molecule Drug Conjugate Targeting Integrin α(V)β(3)

An integrin α(V)β(3)-targeting linear RGD mimetic containing a small-molecule drug conjugate (SMDC) was synthesized by combining the antimitotic agent monomethyl auristatin E (MMAE), an enzymatically cleavable Val-Ala-PABC linker with a linear conjugable RGD mimetic. The structure proposal for the c...

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Detalles Bibliográficos
Autores principales:	Paulus, Jannik, Sewald, Norbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035832/ https://www.ncbi.nlm.nih.gov/pubmed/35480387 http://dx.doi.org/10.3389/fchem.2022.869639

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