Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation

Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8(+) T cells. DCs process internalized protein antigens into peptides that enter the endoplasmic reticulum (ER), bind to major histocompatibility type I (MHC-I) protein complexes, and are transported to t...

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Detalles Bibliográficos
Autores principales: Guttman, Ofer, Le Thomas, Adrien, Marsters, Scot, Lawrence, David A., Gutgesell, Lauren, Zuazo-Gaztelu, Iratxe, Harnoss, Jonathan M., Haag, Simone M., Murthy, Aditya, Strasser, Geraldine, Modrusan, Zora, Wu, Thomas, Mellman, Ira, Ashkenazi, Avi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036094/
https://www.ncbi.nlm.nih.gov/pubmed/35446348
http://dx.doi.org/10.1083/jcb.202111068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036094/
https://www.ncbi.nlm.nih.gov/pubmed/35446348
http://dx.doi.org/10.1083/jcb.202111068

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