FSH mediates estradiol synthesis in hypoxic granulosa cells by activating glycolytic metabolism through the HIF-1α–AMPK–GLUT1 signaling pathway

Owing to the avascular environment within ovarian follicles, granulosa cells (GCs) are believed to live in a hypoxic niche. Follicle-stimulating hormone (FSH)-mediated steroidogenesis is crucial for normal growth and maturation of ovarian follicles, but it remains unclear how FSH stimulates estradio...

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Detalles Bibliográficos
Autores principales: Wu, Gang, Li, Chengyu, Tao, Jingli, Liu, Zhaojun, Li, Xiaoxuan, Zang, Ziyu, Fu, Chen, Wei, Jiayuan, Yang, Yaxing, Zhu, Qian, Zhang, Jia-Qing, Shen, Ming, Liu, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
RESEARCH ARTICLE COLLECTION: Cell Biology (2022)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036125/
https://www.ncbi.nlm.nih.gov/pubmed/35300979
http://dx.doi.org/10.1016/j.jbc.2022.101830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036125/
https://www.ncbi.nlm.nih.gov/pubmed/35300979
http://dx.doi.org/10.1016/j.jbc.2022.101830

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