Effects of Monovalent Salt on Protein-Protein Interactions of Dilute and Concentrated Monoclonal Antibody Formulations

In this study, we used sodium chloride (NaCl) to extensively modulate non-specific protein-protein interactions (PPI) of a humanized anti-streptavidin monoclonal antibody class 2 molecule (ASA-IgG2). The changes in PPI with varying NaCl (C(NaCl)) and monoclonal antibody (mAb) concentration (C(mAb))...

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Detalles Bibliográficos
Autores principales: Xu, Amy Y., Clark, Nicholas J., Pollastrini, Joseph, Espinoza, Maribel, Kim, Hyo-Jin, Kanapuram, Sekhar, Kerwin, Bruce, Treuheit, Michael J., Krueger, Susan, McAuley, Arnold, Curtis, Joseph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036246/
https://www.ncbi.nlm.nih.gov/pubmed/35466277
http://dx.doi.org/10.3390/antib11020024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036246/
https://www.ncbi.nlm.nih.gov/pubmed/35466277
http://dx.doi.org/10.3390/antib11020024

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