A Generic Strategy to Generate Bifunctional Two-in-One Antibodies by Chicken Immunization

Various formats of bispecific antibodies exist, among them Two-in-One antibodies in which each Fab arm can bind to two different antigens. Their IgG-like architecture accounts for low immunogenicity and also circumvents laborious engineering and purification steps to facilitate correct chain pairing...

Descripción completa

Detalles Bibliográficos
Autores principales: Harwardt, Julia, Bogen, Jan P., Carrara, Stefania C., Ulitzka, Michael, Grzeschik, Julius, Hock, Björn, Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036444/
https://www.ncbi.nlm.nih.gov/pubmed/35479092
http://dx.doi.org/10.3389/fimmu.2022.888838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036444/
https://www.ncbi.nlm.nih.gov/pubmed/35479092
http://dx.doi.org/10.3389/fimmu.2022.888838

Ejemplares similares