Transcriptomic and Drug Discovery Analyses Reveal Natural Compounds Targeting the KDM4 Subfamily as Promising Adjuvant Treatments in Cancer

KDM4 proteins are a subfamily of histone demethylases that target the trimethylation of lysines 9 and 36 of histone H3, which are associated with transcriptional repression and elongation respectively. Their deregulation in cancer may lead to chromatin structure alteration and transcriptional defect...

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Detalles Bibliográficos
Autores principales: del Moral-Morales, Aylin, Salgado-Albarrán, Marisol, Ortiz-Gutiérrez, Elizabeth, Pérez-Hernández, Gerardo, Soto-Reyes, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036480/
https://www.ncbi.nlm.nih.gov/pubmed/35480330
http://dx.doi.org/10.3389/fgene.2022.860924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036480/
https://www.ncbi.nlm.nih.gov/pubmed/35480330
http://dx.doi.org/10.3389/fgene.2022.860924

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