Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones

A convenient metal-free synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones has been developed. In this procedure, various structural 2-aminopyrimidines, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism w...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Xue, Ma, Jianting, Zeng, Tingting, Xu, Junyu, Li, Youbin, Wang, Xuesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036825/
https://www.ncbi.nlm.nih.gov/pubmed/35479033
http://dx.doi.org/10.1039/d1ra04319f
_version_ 1784693600493240320
author Cui, Xue
Ma, Jianting
Zeng, Tingting
Xu, Junyu
Li, Youbin
Wang, Xuesong
author_facet Cui, Xue
Ma, Jianting
Zeng, Tingting
Xu, Junyu
Li, Youbin
Wang, Xuesong
author_sort Cui, Xue
collection PubMed
description A convenient metal-free synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones has been developed. In this procedure, various structural 2-aminopyrimidines, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represents an effective strategy towards the synthesis of unsymmetrical 2-aminopyrimidines.
format Online
Article
Text
id pubmed-9036825
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90368252022-04-26 Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones Cui, Xue Ma, Jianting Zeng, Tingting Xu, Junyu Li, Youbin Wang, Xuesong RSC Adv Chemistry A convenient metal-free synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones has been developed. In this procedure, various structural 2-aminopyrimidines, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represents an effective strategy towards the synthesis of unsymmetrical 2-aminopyrimidines. The Royal Society of Chemistry 2021-07-14 /pmc/articles/PMC9036825/ /pubmed/35479033 http://dx.doi.org/10.1039/d1ra04319f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Cui, Xue
Ma, Jianting
Zeng, Tingting
Xu, Junyu
Li, Youbin
Wang, Xuesong
Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
title Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
title_full Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
title_fullStr Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
title_full_unstemmed Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
title_short Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
title_sort metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036825/
https://www.ncbi.nlm.nih.gov/pubmed/35479033
http://dx.doi.org/10.1039/d1ra04319f
work_keys_str_mv AT cuixue metalfreecascadesynthesisofunsymmetrical2aminopyrimidinesfromimidazolateenaminones
AT majianting metalfreecascadesynthesisofunsymmetrical2aminopyrimidinesfromimidazolateenaminones
AT zengtingting metalfreecascadesynthesisofunsymmetrical2aminopyrimidinesfromimidazolateenaminones
AT xujunyu metalfreecascadesynthesisofunsymmetrical2aminopyrimidinesfromimidazolateenaminones
AT liyoubin metalfreecascadesynthesisofunsymmetrical2aminopyrimidinesfromimidazolateenaminones
AT wangxuesong metalfreecascadesynthesisofunsymmetrical2aminopyrimidinesfromimidazolateenaminones

Ejemplares similares